Skin care preparation for external use containing mercaptoindole derivative



【課題】ラン科植物のエビネ属、ガンセキラン属又はその他の偽球茎を有する植物又は搾汁もしくは搾汁からの抽出物から、安全な皮膚外用剤を提供する。 【解決手段】エビネを水洗、カッターで細切りした後、水又はアルコール類で抽出する。あるいは細片を圧搾して搾汁又は搾汁からの抽出液を得る。水もしくはアルコール抽出液又は搾汁もしくは搾汁からの抽出液から、各種クロマトグラフィーを組み合わせて、分画溶出を繰り返し、カラントサイドB原液を得、この原液をβ―グルコシダーゼ酵素で分解して、2−チオール−3−ヒドロキシインドール、2−S−β−D−グルコピラノシル−2−チオール−3−ヒドロキシインドール及び3−o−β−D−グルコピラノシル−2−チオール−3−ヒドロキシインドールを得る。本発明は、これらの化合物に適宜補助的機能性栄養成分を加えて、育毛剤、抗フケ菌剤、美白剤等を得る。天然由来のため、無刺激性で反復使用できる。
PROBLEM TO BE SOLVED: To provide a safe skin care preparation which is used for the skin and is an extract from a plant belonging to Calanthe, Phaiusflavus(Blume) Lindl., or other pseudo-bulbs-having plants in Orchidaceae plants, its juice or an extract from the juice. SOLUTION: 2-Thiol-3-hydroxyindole, 2-S-β-D-glucopyranosyl-2-thiol-3-hydroxyindole, and 3-o-β-D-glucopyranoxyl-2-thiol-3-hydroxyindole are obtained by washing Calanthe discolor with water, finely cutting the washed material with a cutter, extracting the obtained fine pieces with water or an alcohol compound, or compressing the fine pieces to obtain a juice, or obtaining an extract from the juice, repeatedly fractionating and eluting the water extract, the alcohol extract, the juice or the extract with a combination of various kinds of chromatography to obtain a calanthoside B undiluted solution, and then degrading the undiluted solution with β-glucosidase enzyme. These compounds are properly mixed with auxiliary functional nutrients to obtain a hair tonic, an anti-dandruff bacterium agent, a bleaching agent, or the like. These compounds are originated from the natural products, are therefore non-irritative, and can repeatedly be used. COPYRIGHT: (C)2005,JPO&NCIPI




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